The tiny, gas-rich Gulf Arab state of Qatar hosts the biggest U.S. military base in the Middle East. It has evacuated tens of thousands of American citizens from Afghanistan. It has been designated a U.S. "major non-NATO ally." It has even lavished a $400 million jumbo jet on President Donald Trump for use as Air Force One.

None of that protected this quiet peninsula in the Persian Gulf from coming under an Israeli aerial attack on Tuesday as it mediated U.S.-backed negotiations to end the Israel-Hamas war.

Saudi Arabia's Crown Prince Mohammed bin Salman on Tuesday slammed Israel's attack on Hamas in Qatar, calling the strike a "criminal act" in a call with Qatari Emir Sheikh Tamim bin Hamad Al Thani.

Israel notified the United States before it carried out air strikes on senior Hamas leaders in the Qatari capital Doha, a White House official said Tuesday.

"We were informed in advance," the official told AFP on condition of anonymity about the strike on Qatar, a key U.S. ally that's home to a large U.S. military base.

Israeli Prime Minister Benjamin Netanyahu said he ordered the strikes targeting Hamas leaders in Doha on Tuesday, following a deadly shooting in Jerusalem a day earlier claimed by the Palestinian militant group.

Israeli air strikes hit areas of the central and western Syrian cities of Homs and Latakia late Monday, state news agency SANA reported.

Israel struck and destroyed another high-rise building in Gaza City on Monday after warning residents to evacuate, part of an offensive aimed at taking over the largest Palestinian city. The military said it was targeting Hamas observation posts and bombs placed around the 12-story office building.

Over the past several days, Israel has destroyed multiple high-rise buildings in Gaza City, accusing Hamas of putting surveillance infrastructure in them. It has ordered people to flee ahead of its ground offensive into the city of some 1 million residents, which experts say is experiencing famine.

Spanish Prime Minister Pedro Sánchez on Monday ratcheted up his criticism of Israel's actions in the 23-month Israel-Hamas war, to which Israel responded by banning two left-wing Spanish ministers from the country.

A drone fired by Yemen's Houthi rebels breached Israel's multilayered air defenses on Sunday and slammed into the country's southern airport, the Israeli military said, blowing out glass windows, wounding one person and briefly shutting down commercial airspace.

The damage to Ramon Airport appeared limited and flights resumed within hours. The Houthis claimed responsibility for the strike.

U.S. President Donald Trump said Sunday he was issuing a "last warning" to Hamas, saying the Palestinian militant group must accept a deal to release hostages in Gaza.

"The Israelis have accepted my terms. It is time for Hamas to accept as well. I have warned Hamas about the consequences of not accepting. This is my last warning," Trump said on social media, without elaborating further.

Israel's defense minister told Hamas on Monday to lay down its arms or face annihilation, after U.S. President Donald Trump said the militant group must accept a deal to release hostages in Gaza.

The warnings came as the Israeli military intensified its bombings and operations around Gaza City, which it has vowed to capture in a bid to finally defeat Hamas after nearly two years of devastating conflict.