Hamas said it remained open to negotiations while calling for pressure on Israel Wednesday to implement a Gaza truce after its deadliest bombing since the fragile ceasefire began in January.

Thousands of protesters massed in Jerusalem on Wednesday, chanting slogans against Israeli Prime Minister Benjamin Netanyahu who they accuse of undermining democracy and resuming Gaza strikes without regard for hostages.

The health ministry in Hamas-run Gaza said a foreign U.N. worker was killed and five others seriously injured Wednesday by an Israeli strike on their headquarters, as the Israeli army denied hitting a U.N. building.

The health ministry in Hamas-run Gaza on Wednesday published a new death toll from the war with Israel, showing an additional 970 deaths in 48 hours, after Israel intensified deadly strikes on the territory.

The death toll from the war in the Gaza recorded by the ministry at midday on Monday (1000 GMT) stood at 48,577. By midday on Wednesday, the figure had risen to 49,547, it said. Israel launched a wave of strikes on Gaza overnight between Monday and Tuesday, by far the deadliest since a fragile truce began in January.

The Israeli army on Wednesday urged Gazans to evacuate what it called "combat areas" in the north and south of the Palestinian territory, after it resumed air strikes following a ceasefire breakdown.

In a post on X, military spokesman Avichay Adraee warned people in Beit Hanoun, Khirbet Khuza'a and Abasan al-Jadida that "these areas are dangerous combat zones" and they should move to shelters in western Gaza City and Khan Yunis for their own safety.

Yemen’s Houthi rebels said the attack on the base in southern Israel “successfully achieved its objective,” although Israel says the missile was intercepted.

The Houthis say the strike was in response to Israel’s deadly bombardments of Gaza on Tuesday.

It's the third complaint against Israel filed at the U.N. Security Council by Syria's interim government, which took power late last year after ousting longtime President Bashar Assad. The complaint was submitted on March 3 but circulated Tuesday.

Israeli forces have seized territory in southern Syria and launched airstrikes on what Israel says are military sites in Syria, saying the operations aim to protect Israel's borders. Israeli officials have also said that they will not allow the new Syrian military south of Damascus, claiming that they aim to protect the Druze, a minority sect present in both Syria and Israel.

Israel launched a wave of airstrikes across the Gaza Strip on Tuesday, saying it was hitting Hamas targets in its heaviest assault on the territory since a ceasefire took effect in January. The strikes have killed more than 400 people and wounded hundreds more, according to Gaza's Health Ministry, which says over half the dead are women and children.

The Israeli attack could signal the full resumption of war. Israeli Prime Minister Benjamin Netanyahu said Tuesday that all ceasefire negotiations will now take place "under fire."

A Syria war monitor said Israeli jets struck a military site in central Syria on Tuesday, the latest such attack in recent days.

According to the Britain-based Syrian Observatory for Human Rights, "Israeli air strikes targeted a missile battalion" near Homs city, reporting explosions in the area with no immediate word of casualties.

A spokesman for the Palestinian Islamic Jihad militant group was killed in a wave of overnight Israeli air strikes in the Gaza Strip, a senior leader of the group told AFP.