Celta Vigo upset Real Madrid with a 2-1 victory in the round of 16 of the Copa del Rey on Wednesday, and Lionel Messi scored his 21st double to reach 88 goals in 2012, leading Barcelona to a 2-0 win over second-tier club Cordoba.

Having broken German great Gerd Mueller's 40-year-old record for most goals in a year on Sunday, Messi added to his tally in the 11th minute by tapping into an empty net from David Villa's pass.

Players in the final of South America's second most important football tournament fought while leaving the field at halftime, then one team refused to play the second half, charging that security officers attacked its players in the dressing room area.

Officials awarded the Copa Sudamericana title Wednesday night to the Brazilian team Sao Paulo after the referee waited a half hour in hopes the Argentine club Tigre would appear.

Former No. 1 Kim Clijsters ended her career with a 6-3, 6-3 victory over Venus Williams in a ceremonial farewell match.

Clijsters retired after the U.S. Open but organized a match to thank her fans, 13,000 of whom turned up at Antwerp Sports Palace, including Crown Prince Phillipe and Princess Mathilde.

Eli Lilly's experimental Alzheimer's drug has flashed potential to help with mild cases of the disease, but patients and doctors will have to wait a few more years to learn whether regulators will allow the drugmaker to sell it.

Lilly said Wednesday that it will launch another late-stage study of the drug, solanezumab, no later than next year's third quarter. The company's stock slipped in midday trading.

Health officials in the African nation of Gabon say at least 150 people have been sickened by a mosquito-borne illness.

Gabon's Health Minister Marie Josee Ndombi announced Wednesday night in a statement on national television that the patients had been hospitalized with suspected cases of chikungunya fever.

Peruvian striker Paolo Guerrero scored in the first half Wednesday as Brazilian side Corinthians beat Egypt's Al-Ahly 1-0 to advance to the final of the Club World Cup.

Midfielder Douglas sent a perfect cross into the box and Guerrero rose up to make an angled header past the outstretched arms of Al-Ahly goalkeeper Sherif Ekramy in the 30th minute.

The New York Knicks came from 17 points down to beat Brooklyn 100-97 on Tuesday, boosting their lead atop the NBA Eastern Conference standings and inflicting a fifth successive defeat on the suddenly struggling Nets.

Elsewhere on Tuesday, the Los Angeles Clippers brought up their longest winning streak for two decades while their crosstown rivals, the Los Angeles Lakers saw their season lurch closer to crisis with a defeat at the hands of lowly Cleveland.

A Udinese fan has become the center of Italian media attention as the only away supporter to witness his team's 2-0 victory at Sampdoria in Serie A on Monday.

Arrigo Brovedani said he didn't expect to find many other fans in the 4,134-seater away sector on a cold December night, but was stunned to discover he was completely alone.

Manny Pacquiao returned to the Philippines after his knockout loss to Juan Manuel Marquez, saying he will fight again despite some members of his family imploring him to retire.

Shortly after arriving in Manila on Wednesday, Pacquiao told fans "we will rise again" and "there will be future fights."

Arsenal was eliminated from the League Cup quarterfinals in humiliating fashion on Tuesday, losing a penalty shootout 3-2 to fourth-tier Bradford in one of the biggest shocks in the competition for many years.

Thomas Vermaelen struck the decisive spot kick against the post for the Premier League giants, having earlier scored an 87th-minute equalizer to take the game into extra time. The match finished at 1-1 after 120 minutes, despite Arsenal fielding a near full-strength team.